University Of Montréal
Characterization of leukemia-causing oncogenes using Drosophila
Acute myeloid leukemia or AML is a cancer of blood cells. Despite significant progress in recent years, a considerable proportion of afflicted children (40%) and adults (60%) still succumbs to the disease. Based on the conservation of cell division mechanisms among multicellular organisms, we exploit Drosophila fruit flies as a tool to identify functional collaborators of AML-causing oncogenes. This approach will accelerate the discovery of promising targets for therapeutic intervention.