University of Montréal
Podoplanin is a key new player in acute promyelocytic leukemia
Acute promyelocytic leukemias (APL) are uniquely characterized by frequent severe bleeding episodes which are the leading cause of early deaths in these patients. Our proposal capitalizes on a new observation that involves the protein podoplanin as a novel player involved in these complications. We will determine the contribution of this protein compared to other known factors, and investigate the potential benefit of targeting this new protein in APL patients.