University of Western Ontario
Blood cancer type
B-cell acute lymphoblastic leukemia (B-ALL)
Characterization of driver mutations in a mouse model of B-cell leukemia
We have developed a new mouse model of pediatric precursor B-cell acute lymphoblastic leukemia (B-ALL). Our goal is to identify mutations responsible for driving cancer development in these mice. This will be done by sequencing and comparing genomic DNA from leukemia cells and normal cells. We are confident that the scientific community will make use of this model to develop new molecular targeted approaches for treatment of leukemia.