University Health Network
Blood cancer type
acute myeloid leukemia (AML)
High level expression of SOCS2 in high risk acute myeloid leukemia
SOCS2 is a protein which suppresses cytokine signaling and is encoded on chromosome 12. It appears to inhibit Acute Myeloid Leukemia (AML) cell growth by targeting and binding to several key proteins within these AML cells. SOCS2-AS1 is the RNA transcribed from the SOCS2 gene. This project will examine the potential role of SOCS2-AS1 on the growth and chemotherapy resistance of AML cells.