Memorial University of Newfoundland
St. John’s, Newfoundland
Blood cancer type
lymphoma and leukemia
Developing and testing AID inhibitors for leukemia/lymphoma treatment
We are studying a molecule called AID which mutates the DNA of lymphocytes thus transforming them into leukemia or lymphomas. Many studies have shown conclusively that AID expression in lymphomas correlates with poor prognosis. We have identified small molecule drug-like compounds that attach specifically to the part of AID which is responsible for mutating DNA, and thereby inhibit its activity. The goal of this proposal is to (1) refine these molecules to make them more effective, (2) test the hypothesis that these inhibitors can block AID-mediated gain of drug resistance in leukemia or lymphoma. The outcome of this work will pave the way for pre-clinical testing and therapeutic development.