McGill University Health Centre
Co-Applicant: Dr. Margret Shirinian
American University of Beirut
Blood cancer type
Novel Histone Mutations in Leukemia
Leukemia often develops when the master genes that govern how all other genes are ‘read’ are broken by mutation. This disrupts how a cell functions and can result in uncontrolled growth and behaviour, leading to leukemia. In particular, the genes that control how DNA is packaged and organized have been shown to be drivers of leukemic development. In our present study, we will examine new genes in this category for involvement in leukemia.