University of Montréal
Blood cancer type
acute myeloid leukemia (AML)
eIF4E drives production of extracellular vesicles in AML
Dysregulation of a cancer-causing protein, eIF4E, is linked to many cancers including cute myeloid leukemia (AML). We discovered that eIF4E overexpression drives changes to the surface architecture of cancer cells, coating them in a sugar called hyaluronan, which supports the cancer phenotype. We also found that eIF4E drove the formation and release of hyaluronan-based vesicles into the space between cells. We will investigate whether these vesicles carry cargoes that can reprogramme the environment to support the growth of cancer cells and allow them to evade the effects of chemotherapy.