British Columbia Cancer Agency
Vancouver, British Columbia
Regulation and interactions of the oncogenic transcription factor MEIS1
MEIS1 is a protein that controls gene expression. Overexpression of MEIS1 is involved in many blood cancers including leukemias. Using a powerful new tool to modify the genome of human or mouse cells we have modified the MEIS1 gene in both human leukemic cell lines and in a novel mouse strain so that we can more easily detect its expression (via a fluorescence reporter) and purify it along with associated proteins (via a special tag sequence). We will now exploit these models to better understand how MEIS1 expression is regulated and with what proteins it interacts with in order to identify new methods to block MEIS1 expression or function in leukemia.