University of Laval
Québec City, Québec
Co-Applicant: Dr. Philippe Tessier
Blood cancer type
acute myeloid leukemia (AML)
Biology of S100A8 and S100A9 proteins in human AML
Our team has recently studied the role of S100A8 and S100A9 proteins in acute myeloid leukemias. We found that S100A8 maintains the undifferentiated state of leukemic cells while S100A9 can induce their differentiation. In the current proposal, we aim to better understand the effects of the proteins, their receptors and their cellular pathways both in vivo and in vitro to move towards clinical application in the next few years.