British Columbia Cancer Agency
Blood cancer type
The onco-ribosome as a novel drug target in leukemias
In our lab, we discovered a cancer-specific variation in T-cell leukemia in the ribosome, a cell component essential to synthesize proteins. Interestingly, this variation is located in a ribosomal region that is the target of a major group of antibiotics. The goal of this project is to test the hypothesis that leukemia cells with this ribosomal variation can be selectively killed by antibiotics, which would provide a new therapeutic option.