Centre de Recherche l'Hôpital Maisonneuve-Rosemont
Rational co-stimulation modulation for adoptive immunotherapy
The treatment of blood cancer using immune cells that have been previously “educated” in the laboratory is highly promising. However, several limitations need to be overcome before this form of therapy reaches its full potential. This proposal is about modulating certain signals the immune cells receive in the laboratory and in vivo, so that they acquire the best characteristics to recognize and kill leukemia cells.