Co-Applicant: Dr. Lincoln Stein
Ontario Institute for Cancer Research
Blood cancer type
Identifying non-coding driver mutations in diffuse large B-cell lymphoma
DNA sequencing studies of Diffuse large B-cell (DLBC) lymphoma patients have revealed that 99% of their cancer-associated mutations involve non-protein coding DNA. This project will examine the hypothesis that some of these non-coding mutations promote the cancerous behavior of DLBC lymphoma cells by affecting the regulation of important genes. This collaborative study will examine combinations of coding and non-coding mutations that will reveal which biochemical signaling pathways are implicated in determining the treatment response of lymphoma cases. Once identified many of these pathways can be targeted with new drugs.