Québec City, Québec
Challenging the Leukemia Stem Cell Theory in Human Acute Leukemias
Testing human leukemic cells in immunodeficient mice is the state-of-the-art approach to understand their in vivo behaviour and assay their engrafting and self-renewing capacities. In the past 20 years, the data generated in such models led us to believe that a subset of cells, called leukemic stem cells, are at the apex of the tumour hierarchy. However, our recent results challenge this dogma and new sequencing technologies will help testing it.