University of Manitoba
Role of follicular helper T cell subsets in chronic lymphocytic leukemia
Leukemia cells disrupt the immune system by invading immunological tissues such as lymph nodes and bone marrow, where they interact with other cells that help the leukemia proliferate and become resistant to chemotherapy. Dr. Marshall’s group has discovered specific abnormalities of T lymphocytes in leukemia patients and is determining how these T cell abnormalities contribute to disease progression. These discoveries will identify new biomarkers predictive of disease outcomes and new targets for therapy.