University of Toronto
Investigating a novel role for INPP4B in leukemic stem cell maintenance
Dr. Salmena’s research group has identified INPP4B as a biomarker to identify leukemia patients that are likely to fail therapy. Subsequently, they have discovered that INPP4B is important for maintaining the ‘health’ of the leukemia stem cells (LSC) that drive aggressive disease and relapse in leukemia. The Salmena group will study how INPP4B contributes to stemness and use this knowledge to identify new therapies to treat leukemia.