Elucidation of the functional role of Complement Factor D in Acute Myeloid Leukemia.
Acute myeloid leukemia (AML) is the second most common type of leukemia in both children and adults for which the survival rate remains poor. The proposed research intends to elucidate the function of a novel prognosis marker in AML. In particular, we will characterize its role on cancer cells aggressiveness and communication with their specialized microenvironment. This marker is a potentially actionable target for the development of innovative therapies to cure leukemia.