University of Toronto
Inhibiting mitochondrial RNA polymerase in acute myeloid leukemia
Acute myeloid leukemia on a particular cellular energy pathway for growth and viability. One enzyme, mitochondrial RNA polymerase, controls the level of this energy pathway. In the current application we propose an animal model and cell culture proof-of-concept study with a selective inhibitor of the enzyme. This project will help us understand whether designing drugs against this enzyme might be a useful therapeutic strategy for AML.