University Health Network
Manipulating Gamma Delta T-cell metabolism for Improved Cytotoxicity in Hematological Malignancies
Harnessing the potential of the immune system to combat blood cancers represents a new approach that has started to change the standard of care. A growing body of evidence indicates that as immune cells switch from an inactive mode to a cancer-killing mode they undergo radical changes in how they take up and use nutrients and metabolites. In this proposal we aim to explore how gamma/delta T-cells change their nutritional requirements upon activation to a cancer-killing state. Having determined which nutrients these cells rely on to and how they are re-programmed to kill lymphoma cells, we will then attempt to genetically manipulate the metabolism of these cells them for optimal anti-lymphoma activity. This could lead to the development of an entirely new type of cellular therapy to treat blood cancers.