British Columbia Cancer Agency
Vancouver, British Columbia
Role of MYC in a new de novo model of MYC-induced human AML
The roles of specific gene alterations in patients’ leukemic cells are difficult to study because of many other mutations typically also present. The applicants have recently discovered a method of creating human leukemia experimentally by forcing normal human blood precursors to overexpress a single gene broadly implicated in human leukemia. They will now analyze the cells and molecules affected and thereby identify important targets to later test in patients’ cells.