Jewish General Hospital/Lady Davis Institute for Medical Research
Co-Applicant: Dr. Trang Hoang
IRIC, University of Montréal
Blood cancer type
Pediatric acute lymphoblastic leukemia (ALL)
Targeting eIF2(alpha) phosphorylation in T-cell acute lymphoblastic leukemia
Standard of care in pediatric T-cell acute lymphoblastic leukemia (T-ALL) result in high cure rates, however the long duration of such drastic chemotherapy in young people irreversibly alters their quality of life. Moreover, prognosis is appalling in adolescent/adult T-ALL. We previously showed that leukemia initiating cells are slowly dividing cells that ‘lie low’ to resist chemotherapy. We will identify the mechanism that refrain these cells from dividing, with the objective of releasing the brake and sensitizing these cells to treatment.