Princess Margaret Hospital
Role of Mitochondrial Biogenesis and Mitophagy in AML Stem Cells
Acute myeloid leukemia is an aggressive type of blood cancer that kills over 1,000 people every year in Canada. Current therapies are often ineffective because they fail to kill a special type of cells known as leukemia stem cells. Our proposed studies will study how mitochondria, the powerhouses of the cell, function in leukemia stem cells and explore new strategies to destroy these cells by targeting the mitochondria.