Determinants of oncogenic penetrance of TET2 mutations in aging individuals
The incidence of blood cancers greatly increases with age. However, there is no test to identify individuals at risk. We have documented mutation in a gene called TET2 in a small proportion of aging individuals. Since this gene is frequently mutated in blood cancers of older people, we think that it may be a predisposing factor. To prove our hypothesis, we need to study a larger number of individuals and see if they develop such cancers with time. Fortunately, we have started our study 10-15 years ago with several thousand subjects. Therefore, we will be able to answer this question in a short lapse of time. If our hypothesis holds true, we will be able to identify individuals at risk of blood cancer as it is done for other cancers such as prostate, colon or breast.