IWK Health Centre
Halifax, Nova Scotia
Elucidating pathogenesis and downstream targets in NUP98-NSD1 induced AML
Acute myeloid leukemia (AML) is an aggressive blood cancer requiring better treatments. We will use zebrafish to determine why children with a newly discovered gene abnormality have a particularly deadly form of AML. We will put NUP98-NSD1 and FLT3 human cancer genes into zebrafish. We will study how these genes impact zebrafish blood development causing leukemia. Compounds that restore normal blood development in zebrafish may represent new treatments for leukemia.