Clinical Research Institute of Montreal
AID expression sensitizes B cell lymphoma to UNG inhibition
A large proportion of non-Hodgkin lymphomas become resistant to the available therapies, so new alternatives are needed. We propose to exploit a vulnerability created by the enzyme AID, which is present in many lymphomas, to specifically target these cancer cells. We will show that inhibiting the non-essential DNA repair factor UNG allows AID to produce catastrophic damage at the chromosome ends, permanently arresting lymphoma cells proliferation and thereby tumour growth.